Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
ABL1 is a protein tyrosine kinase that is implicated in various cancers, including in chronic myelogenous leukemia (CML), through fusion of the ABL gene, in chromosome 9, and the BCR gene, in chromosome 22. This subchallenge tests the ability of computational methods to predict the effect of target mutations on small molecule binding affinities. The dataset consists of Kd values for two compounds versus the wild type and five mutants of the nonphosphorylated ABL1 protein, ABL1(F317I), ABL1(F317L), ABL1(H396P), ABL1(Q252H), and ABL1(T315I).
File Name | Description | Date Added | Download |
---|---|---|---|
GC3_ABL1.zip | GC3_ABL1 Dataset from Grand Challenge 3 | 03:46pm February 6, 2020 | Download |
File Name | Description | Date Added | Download |
---|---|---|---|
No Document Files |